MAINTAIN - MAintain Functions and INTrinsec capacities with Aging : Preventive and Personalized INterventional Research

Equipe constitutive du CERPOP, UMR 1295, unité mixte INSERM - Université Toulouse III Paul Sabatier
 

2019 :
  • André L, Gallini A, Montastruc F, Coley N, Montastruc JL, Vellas B, Andrieu S, Gardette V; MAPT/DSA study group. Anticholinergic exposure and cognitive decline in older adults: effect of anticholinergic exposure definitions in a 3-year analysis of the multidomain Alzheimer preventive trial (MAPT) study. Br J Clin Pharmacol. 2019 Jan;85(1):71-99. doi: 10.1111/bcp.13734.
     
  • Ashraf A, Stosnach H, Parkes HG, Hye A, Powell J, So PW; AddNeuroMed consortium (Vellas B collaborator). Pattern of Altered Plasma Elemental Phosphorus, Calcium, Zinc, and Iron in Alzheimer's Disease. Sci Rep. 2019 Feb 28;9(1):3147. doi: 10.1038/s41598-018-37431-8 Erratum in: Sci Rep. 2019 Apr 16;9(1):6343.
     
  • Bateman RJ, Blennow K, Doody R, Hendrix S, Lovestone S, Salloway S, Schindler R, Weiner M, Zetterberg H, Aisen P, Vellas B. Plasma Biomarkers of AD Emerging as Essential Tools for Drug Development: An EU/US CTAD Task Force Report. J Prev Alzheimers Dis. 2019;6(3):169-17 doi: 10.14283/jpad.2019.21.
     
  • Bauer JM, Cruz-Jentoft AJ, Fielding RA, Kanis JA, Reginster JY, Bruyère O, Cesari M, Chapurlat R, Al-Daghri N, Dennison E, Kaufman JM, Landi F, Laslop A, Locquet M, Maggi S, McCloskey E, Perna S, Rizzoli R, Rolland Y, Rondanelli M, Szulc P, Vellas B, Vlaskovska M, Cooper C. Is There Enough Evidence for Osteosarcopenic Obesity as a Distinct Entity ? A Critical Literature Review. Calcif Tissue Int. 2019. 105 (2), 109-12 doi: 10.1007/s00223-019-00561-w.
     
  • Belger M, Haro JM, Reed C, Happich M, Argimon JM, Bruno G, Dodel R, Jones RW, Vellas B, Wimo A. Determinants of time to institutionalisation and related healthcare and societal costs in a community-based cohort of patients with Alzheimer's disease dementia. Eur J Health Econ. 2019 Apr;20(3):343-35 doi: 10.1007/s10198-018-1001-3.
     
  • Boccardi V, Westman E, Pelini L, Lindberg O, Muehlboeck JS, Simmons A, Tarducci R, Floridi P, Chiarini P, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Spenger C, Wahlund LO, Lovestone S, Mecocci P. Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer's Disease. Front Aging Neurosci. 2019 Jan 17;10:439. doi: 10.3389/fnagi.2018.00439.
     
  • Bowman GL, Dodge HH, Guyonnet S, Zhou N, Donohue J, Bichsel A, Schmitt J, Hooper C, Bartfai T, Andrieu S, Vellas B; MAPT/DSA Study Group. A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial. Alzheimers Dement (N Y). 2019;5:953–963. doi:10.1016/j.trci.2019.11.004.
  • Chhetri JK, Chan P, Ma L, Peng D, Rodríguez-Mañas L, Cesari M, Vellas B. Prevention of Disability in the Frail Chinese Older Population J Frailty Aging. 2019;8(1):2-6. doi: 10.14283/jfa.20127.
     
  • Chhetri JK, Chan P, Vellas B, Touchon J, Gauthier S. Report from the First Clinical Trials on Alzheimer's Disease (CTAD) Asia-China 2018 : Bringing together Global Leaders. J Prev Alzheimers Dis. 2019;6(2):144-147. doi: 10.14283/jpad.2012.
     
  • Chhetri JK, Mahara G, Vellas B, Cesari M. Burden of Frailty in Post-Disaster Low-Income Countries: An Example From Nepal. Disaster Med Public Health Prep. 2019 Apr;13(2):104. doi: 1017/dmp.2018.50.
     
  • Coley N, Ngandu T, Lehtisalo J, Soininen H, Vellas B, Richard E, Kivipelto M, Andrieu S; HATICE, FINGER, and MAPT/DSA groups. (Rolland Y, Guyonnet S, Abellan van Kan G, Villars H, Voisin T collaborators) Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials. Alzheimers Dement. 2019. 15(6):729-741. doi: 10.1016/j.jalz.2019.03.005.
     
  • Cummings J, Blennow K, Johnson K, Keeley M, Bateman RJ, Molinuevo JL, Touchon J, Aisen P, Vellas B. Anti-Tau Trials for Alzheimer's Disease: A Report from the EU/US/CTAD Task Force. J Prev Alzheimers Dis. 2019;6(3):157-163. doi: 10.14283/jpad.2019.14.
     
  • de Mauleon A, Soto M, Ousset PJ, Nourhashemi F, Lepage B, Vellas B. Potentially modifiable factors associated with agitation and aggression in Alzheimer's disease: results of the ICTUS study. Int Psychogeriatr. 2019 Oct;31(10):1509-1516. doi: 10.1017/S1041610218001990.
     
  • de Souto Barreto P, Rolland Y, Vellas B, Maltais M. Association of Long-term Exercise Training With Risk of Falls, Fractures, Hospitalizations, and Mortality in Older Adults: A Systematic Review and Meta-analysis. JAMA Intern Med. 2019. 179 (3), 394-405. doi: 10.1001/jamainternmed.2018.5406.
     
  • Delrieu J, Payoux P, Carrié I, Cantet C, Weiner M, Vellas B, Andrieu S. Multidomain intervention and/or omega-3 in nondemented elderly subjects according to amyloid status. Alzheimers Dement. 2019 Nov;15(11):1392-1401. doi: 10.1016/j.jalz.2019.07.008.  
     
  • Dietlin S, Soto M, Kiyasova V, Pueyo M, de Mauleon A, Delrieu J, Ousset PJ, Vellas B. Neuropsychiatric Symptoms and Risk of Progression to Alzheimer's Disease Among Mild Cognitive Impairment Subjects. J Alzheimers Dis. 2019. 70 (1), 25-34. doi: 10.3233/JAD-190025.
     
  • Egan MF, Kost J, Voss T, Mukai Y, Aisen PS, Cummings JL, Tariot PN, Vellas B, van Dyck CH, Boada M, Zhang Y, Li W, Furtek C, Mahoney E, Harper Mozley L, Mo Y, Sur C, Michelson D. Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease. N Engl J Med. 2019 Apr 11;380(15):1408-1420. doi: 10.1056/NEJMoa1812840.
     
  • Frisoni GB, Barkhof F, Altomare D, Berkhof J, Boccardi M, Canzoneri E, Collij L, Drzezga A, Farrar G, Garibotto V, Gismondi R, Gispert JD, Jessen F, Kivipelto M, Lopes Alves I, Molinuevo JL, Nordberg A, Payoux P, Ritchie C, Savicheva I, Scheltens P, Schmidt ME, Schott JM, Stephens A, van Berckel B, Vellas B, Walker Z, Raffa N. AMYPAD Diagnostic and Patient Management Study: Rationale and design. Alzheimers Dement. 2019 Mar;15(3):388-399. doi: 10.1016/j.jalz.2009.003.
     
  • Gabelle A, Gutierrez LA, Jaussent I, Ben Bouallegue F, De Verbizier D, Navucet S, Grasselli C, Bennys K, Marelli C, David R, Mariano-Goulart D, Andrieu S, Vellas B, Payoux P, Berr C, Dauvilliers Y. Absence of Relationship Between Self-Reported Sleep Measures and Amyloid Load in Elderly Subjects. Front Neurol. Front Neurol. 2019 Sep 13;10:989. doi: 10.3389/fneur.2000989.  
     
  • Gabelle A, Jaussent I, Bouallègue FB, Lehmann S, Lopez R, Barateau L, Grasselli C, Pesenti C, de Verbizier D, Béziat S, Mariano-Goulart D, Carlander B, Dauvilliers Y; Alzheimer's Disease Neuroimaging Initiative; Multi-Domain Intervention Alzheimer's Prevention Trial study groups. (Rolland Y, Abellan van Kan G, Coley N, Vellas B, Guyonnet S, Villars H, Voisin T, Andrieu S, Cantet C collaborators). Reduced brain amyloid burden in elderly patients with narcolepsy type 1. Ann Neurol. 2019. 85(1):74-83. doi: 10.1002/ana.25373.
     
  • Gallini A, Yrondi A, Cantet C, Poncet M, Vellas B, Schmitt, Andrieu S. Red Blood Cell Omega-3 Fatty Acid Composition and Psychotropic Drug Use in Older Adults: Results from the MAPT Study. J Nutr Health Aging. 2019;23(9):805–812. doi: 10.1007/s12603-019-1252-4.
     
  • Gauthier S, Alam J, Fillit H, Iwatsubo T, Liu-Seifert H, Sabbagh M, Salloway S, Sampaio C, Sims JR, Sperling B, Sperling R, Welsh-Bohmer KA, Touchon J, Vellas B, Aisen P. Combination Therapy for Alzheimer's Disease: Perspectives of the EU/US CTAD Task Force. J Prev Alzheimers Dis. 2019;6(3):164-168. doi: 10.14283/jpad.2019.12.  
     
  • Giudici KV, de Souto Barreto P, Guerville F, Beard J, Araujo de Carvalho I, Andrieu S, Rolland Y, Vellas B; MAPT/DSA group. Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study). Exp Gerontol. 2019 Nov;127:110716. doi: 10.1016/j.exger.2019.110716.
     
  • Giudici KV, de Souto Barreto P, Soriano G, Rolland Y, Vellas B. Defining Vitality: Associations of Three Operational Definitions of Vitality with Disability in Instrumental Activities of Daily Living and Frailty among Elderly Over a 3-Year Follow-Up (MAPT Study). J Nutr Health Aging. 2019. 23(4):386-392. doi: 10.1007/s12603-019-1175-0.
     
  • Giudici KV, Guyonnet S, Rolland Y, Vellas B, de Souto Barreto P, Nourhashemi F; MAPT/DSA Group. Body Weight Variation Patterns as Predictors of Cognitive Decline over a 5 Year Follow-Up among Community-Dwelling Elderly (MAPT Study). Nutrients. 2019 Jun 18;11(6):1371. doi: 10.3390/nu11061371.
     
  • Guerville F, de Souto Barreto P, Giudici KV, Rolland Y, Vellas B; MAPT/DSA Group. Association of 3-Year Multidomain Intervention and Omega-3 Supplementation with Frailty Incidence. J Am Geriatr Soc. 2019. 67 (8), 1700-1706. doi: 10.1111/jgs.15994.
     
  • Guerville F, de Souto Barreto P, Taton B, Bourdel-Marchasson I, Rolland Y, Vellas B; Multidomain Alzheimer Preventive Trial (MAPT)/Data Sharing Alzheimer (DSA) Group. Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults. Clin J Am Soc Nephrol. 2019 Nov 7;14(11):1597-160 doi: 10.2215/CJN.03750319.
     
  • Herr M, Cesari M, Landre B, Ankri J, Vellas B, Andrieu S; MAPT/DSA Study Group. Factors associated with changes of the frailty status after age 70: Findings in the MAPT study. Ann Epidemiol. 2019 Jun;34:65-70.e1. doi: 10.1016/j.annepidem.2019.03.008.
     
  • Kunkle BW, Grenier-Boley B, Sims R,... Vellas B, ... Pericak-Vance MA. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.Nat Genet. 2019 Mar;51(3):414-430. doi: 10.1038/s41588-019-0358-2.
     
  • Maltais M, Aubertin-Leheudre M, Dray C, Fielding RA, Rolland Y, Cesari M, Vellas B. Highlights from the 2019 International Congress on Frailty and Sarcopenia Research. J Frailty Aging. 2019;8(3):117-119. doi: 10.14283/jfa.2019.13.
     
  • Maltais M, Boisvert-Vigneault K, Rolland Y, Vellas B, de Souto Barreto P; MAPT/DSA Study Group. Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The MAPT study. Exp Gerontol. 2019 Dec;128:11075 doi: 10.1016/j.exger.2019.11075
     
  • Maltais M, de Souto Barreto P, Hooper C, Payoux P, Rolland Y, Vellas B; MAPT/DSA Study Group. Association between brain b-amyloid and frailty in older adults. J Gerontol A Biol Sci Med Sci. 201 74 (11), 1747-1752. doi: 10.1093/gerona/glz00
     
  • Maltais M, de Souto Barreto P, Moon SY, Rolland Y, Vellas B; MAPT/DSA Study Group. Prospective association of white matter hyperintensity volume and frailty in older adults. Exp Gerontol. 2019 Apr;118:51-54. doi: 1016/j.exger.2019.01.007.
     
  • Maltais M, de Souto Barreto P, Pothier K, Cantet C, Andrieu S, Rolland Y, Vellas B; MAPT/DSA Study Group. Lifestyle multidomain intervention, omega-3 supplementation, or both for reducing the risk of developing clinically relevant depressive symptoms in older adults with memory complaints? Secondary analysis from the MAPT trial. Exp Gerontol. 2019 Jun;120:28-34. doi: 10.1016/j.exger.2019.0010.
     
  • Maltais M, de Souto Barreto P, Rolland Y, Vellas B. Is Fat Mass Cross-Sectionally Associated with Cortical Aβ Load in the Human Brain? J Nutr Health Aging. 2019;23(2):207-210. doi: 10.1007/s12603-018-1121-6.
     
  • Maltais M, de Souto Barreto P, Rolland Y, Vellas B. The Association of ApoE ε4 Status with Lower Limb Function and Handgrip Strength in Older Adults. J Frailty Aging. 2019;8(2):62-66. doi: 10.14283/jfa.2019.7.
     
  • Maltais M, Rolland Y, Haÿ PE, Armaingaud D, Vellas B, de Souto Barreto P. Six-month observational follow-up on activities of daily living in people with dementia living in nursing homes after a 6-month group based on either exercise or social activities. Aging Clin Exp Res. 2019 Mar;31(3):361-366. doi: 10.1007/s40520-018-0984-z.
     
  • Maltais M, Rolland Y, Vellas B, Haÿ PE, Armaingaud D, Cestac P, Rouch L, Cesari M, de Souto Barreto P. Effect of Exercise on Behavioral Symptoms and Pain in Patients With Dementia Living in Nursing Homes. Am J Alzheimers Dis Other Demen. 2019 Mar;34(2):89-94. doi: 10.1177/1533317518803773.
     
  • Masciocchi E, Maltais M, Rolland Y, Vellas B, de Souto Barreto P. Time Effects on Physical Performance in Older Adults in Nursing Home: A Narrative Review. J Nutr Health Aging. 2019;23(6):586-594: doi: 10.1007/s12603-019-1199-5.
     
  • Parrotta I, Maltais M, Rolland Y, Spampinato DA, Robert P, de Souto Barreto P, Vellas B; MAPT/DSA group. The association between apathy and frailty in older adults: a new investigation using data from the Mapt study. Aging Ment Health. 2019 Aug 14:1-5. doi: 10.1080/13607863.2019.1650890.
     
  • Pothier K, Saint-Aubert L, Hooper C, Delrieu J, Payoux P, de Souto Barreto P, Vellas B; MAPT/DSA Study Group. Cognitive changes of older adults with an equivocal amyloid load. J Neurol. 2019 Apr;266(4):835-843. doi: 10.1007/s00415-019-09203-5.
     
  • Rodriguez-Mañas L, Laosa O, Vellas B, Paolisso G, Topinkova E, Oliva-Moreno J, Bourdel-Marchasson I, Izquierdo M, Hood K, Zeyfang A, Gambassi G, Petrovic M, Hardman TC, Kelson MJ, Bautmans I, Abellan G, Barbieri M, Peña-Longobardo LM, Regueme SC, Calvani R, De Buyser S, Sinclair AJ; European MID-Frail Consortium. Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus. J Cachexia Sarcopenia Muscle. 201 10 (4), 721-733. doi: 10.1002/jcsm.124.
     
  • Rollan Y, Barreto PS, Maltais M, Guyonnet S, Cantet C, Andrieu S, Vellas B. Effect of Long-Term Omega 3 Polyunsaturated Fatty Acid Supplementation with or without Multidomain Lifestyle Intervention on Muscle Strength in Older Adults: Secondary Analysis of the Multidomain Alzheimer Preventive Trial (MAPT). Nutrients. 2019 Aug 16;11(8):1931. doi: 3390/nu11081931.
     
  • Rouch L, Cestac P, Hanon O, Ruidavets JB, Ehlinger V, Gentil C, Cool C, Helmer C, Dartigues JF, Bouhanick B, Chamontin B, Sallerin B, Vellas B, Marquié JC, Esquirol Y, Andrieu S. Blood pressure and cognitive performances in middle-aged adults: the Aging, Health and Work longitudinal study. J Hypertens. 2019 Jun;37(6):1244-1253 doi: 10.1097/HJH.0000000000002013.
     
  • Slot RER, Sikkes SAM, Berkhof J, Brodaty H, Buckley R, Cavedo E, Dardiotis E, Guillo-Benarous F, Hampel H, Kochan NA, Lista S, Luck T, Maruff P, Molinuevo JL, Kornhuber J, Reisberg B, Riedel-Heller SG, Risacher SL, Roehr S, Sachdev PS, Scarmeas N, Scheltens P, Shulman MB, Saykin AJ, Verfaillie SCJ, Visser PJ, Vos SJB, Wagner M, Wolfsgruber S, Jessen F; Alzheimer's Disease Neuroimaging Initiative; DESCRIPA working group; INSIGHT-preAD study group; SCD-I working group, van der Flier WM. (Vellas B collaborator) Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia. Alzheimers Dement. 2019 Mar;15(3):465-476. doi: 10.1016/j.jalz.2018.10.003.
     
  • Soriano G, De Barreto PS, Rolland Y, Plessz M, Goisser S, Guyonnet S, Fougère B, Vellas B, Andrieu S, Sourdet S; Groupe DSA MAPT. Ready-meal consumption in older people: association with obesity and dietary intake. Aging Clin Exp Res. 2019 Jun;31(6):855-861. doi: 10.1007/s40520-018-1043-5
     
  • Vellas B, Bain LJ, Touchon J, Aisen PS. Advancing Alzheimer's Disease Treatment: Lessons from CTAD 2018. J Prev Alzheimers Dis. 2019;6(3):198-203. doi: 10.14283/jpad.2019.11.
     
  • Vermunt L, Sikkes SAM, van den Hout A, Handels R, Bos I, van der Flier WM, Kern S, Ousset PJ, Maruff P, Skoog I, Verhey FRJ, Freund-Levi Y, Tsolaki M, Wallin ÅK, Olde Rikkert M, Soininen H, Spiru L, Zetterberg H, Blennow K, Scheltens P, Muniz-Terrera G, Visser PJ; Alzheimer Disease Neuroimaging Initiative; AIBL Research Group; ICTUS/DSA study groups (Coley N, Andrieu S, Ousset S, Vellas B, Cantet C collaborators). Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype. Alzheimers Dement. 2019. 15(7):888-898. doi: 10.1016/j.jalz.2019.04.001.
     
  • Waters DL, Qualls CR, Cesari M, Rolland Y, Vlietstra L, Vellas B. Relationship of Incident Falls with Balance Deficits and Body Composition in Male and Female Community-Dwelling Elders. J Nutr Health Aging. 2019;23(1):9-13. doi: 10.1007/s12603-018-1087-4.