19 oct.

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Team 4

Genomics, biotherapy and public health : interdisciplinary approach

UMR1027, INSERM-UNIVERSITY PAUL SABATIER Toulouse III joint research unit

Emmanuelle Rial-Sebbag
- Manager @ 05 61 14 56 16    Team sheet

Team 4: "Genomics, biotherapy and public health: interdisciplinary approach", is rooted in analyses of genomic data and immunogenetics; it is an interdisciplinary team that interfaces biomedical sciences and human and social sciences. It consists of 1 CNRS researcher, 6 university or hospital and university academics (with 2 Inserm interface contracts), 1 Inserm emeritus researcher, 2 post-doctoral fellows, 10 PhD students, 3 temporary employed engineers, 1 temporary employed administrative assistant and 3 to 6 students. It interacts with the societal platform "Genetics and society" of genopole Toulouse Midi-Pyrénées.

Expected health effects

The expected outcomes are scenarios for implementing genetics in public health actions and a help in validation and decision regarding the use of genetic testing in multifactorial diseases, the consequences of sequencing for clinical applications and the implications of innovative therapies for the health system. They rely on a prior multidisciplinary analysis incorporating especially ethical issues consideration. Tools for facilitating data sharing, biological sample exchanges and governance of biobanks are produced.

Cooperations / Partnerships

Contrats européens FP7
GEN2PHEN Genotype to phenotype, 2008-12
TECHGENE Technological innovation of high throughput molecular diagnostics 2009-12
CAGEKID Cancer genomics of the kidney, 2010-13
BioSHaRE-EU Biobank Standardisation and Harmonisation for Research Excellence in EU, 2011-15
GEUVADIS Sharing capacity across Europe in high-throughput sequencing, 2010-13
MeDALL Mechanisms of the Development of ALLergy, 2010-14
ESGI  European Sequencing and Genotyping Infrastructure, ESFRI 2011-15
EuroTARGET TArgeted therapy in Renal cell cancer, 2011-16
PHGENII (DG Sanco): European Best Practice Guidelines for Genome-based Information and Technologies, 2009-12

Coord subvention IRESP : Tests génétiques en accès libre sur Internet
Participation ANR sur régulation cellules souches: THERACELS

Bilateral Collaborations : Canada, Japon, US, Tunisie, Pays-Bas

Réseaux internationaux : P3G, IIREB, EPHLN, ICGC

Methods and tools

1. Analyses in law and bioethics : European law, health law
2. Epidemiological, legal, sociological surveys and investigations (qualitative and quantitative methodologies in sociology of science, sociology of health and health psychology; mixed methods)
3. Know-how on the biobanks of human biological material and data, including genetics
4. Knowledge on ethical and legal aspects of research in biology, genetics, clinical research and biotherapy
5. Genotyping and Analysis of polymorphic markers in the HLA region and other regions applied Immunogenetics including rheumatoid arthritis
6. Experience of interdisciplinarity between biological and health sciences and social sciences and humanities
7. Experience and detailed knowledge of European institutions and research and innovation framework programmes
8. Experience and thorough knowledge of research infrastructures in biology at French and European level, especially their ethical and societal aspects.



Ongoing projects

Projets européens FP7 / EU supported FP7 projects
MEDALL ; Mechanisms of the Development of ALLergy (Coordination France, Inserm, J Bousquet, 2010 - 2015; ELSI WP leader A. Cambon-Thomsen) - GA  261357  
BIOSHARE : Biobank Standardization and Harmonization for Research Excellence in the European Union (Coordination The Netherlands, University Medical Centre Groningen (UMCG), R. Stolk , 2010 - 2015; ELSI tasks participant and BRIF leader A. Cambon-Thomsen) - GA 261433 
ESGI : European Sequencing and Genotyping Infrastructure (Coordination Allemagne, Max-Planck-Institute for Molecular Genetics ;  S Sauer, 2011 - 2015; ELSI WP leader A. Cambon-Thomsen) - GA 262055. 
EUROTARGET : European collaborative project on Targeted therapy in renal cell cancer - genetic and biomarkers (Coordination The Netherlands, Radboud University Medical Center ; Bart Kiemeney, 2011 - 201 ; ELSI WP leader A. Cambon-Thomsen) - GA 259939 
BBMRI-LPC : Biobank and biomolecular research infrastructure, Large prospective cohort. (Coordination Finland and The Netherlands ; Markus Perola, and Leiden University Medical Center (LUMC), Gertjan van Ommen ; 2013-2017. ELSI tasks co-leader E. Rial-Sebbag) - GA313010;  
EUCELLEX : Cell based regenerative medicine : new challenges for EU legislation and governance. (Coordination France, Inserm, E. Rial-Sebbag, UMR 1027; 2013 - 2016 ) - GA 601806   
3 GBTEST : Introducing diagnostic applications of 3Gb-testing' in human genetics. (Coordination : The Netherlands, University Medical Centre Leiden, Egbert Bakker;  2013-2015; ELSI WP leader A. Cambon-Thomsen ;GA 602269
Action COST CHIP ME: Citizen's Health through public-private Initiatives: Public health, Market and Ethical perspectives. Coordination Italie, Elia Stupka ;A. Cambon-Thomsen member management committee;participants:E. Rial-Sebbag, A Blasimme) 2013-2016; ISCH Cost action N° IS1303
ROTM- Rights on the move: Rainbow families in Europe projet co-financé par l'UE - 2013-2015 (Coordination: Italie, University of Trento;Alexander Schuster ;  Responsable UMR 1027:AM Duguet)
BRIF initiative: Bioresources research impact factor initiative  (Coordination : A. Cambon-Thomsen; Project manager : L. Mabile). 2010-2017.

Projets nationaux, régionaux 
IBISS : Incorporation biologique et inégalités sociales de santé (Coordination C. Delpierre, Inserm; Responsable d'axe SHS: E. Rial-Sebbag; financement ANR)
- Marqueurs génétiques et prise en charge de la Polyarthrite rhumatoïde R. Financé par AMPS (Association Midi-Pyrénées Santé; Responsable Adeline Ruyssen-Witrand)
Information de la parentèle en génétique: enjeux et mise en œuvre  en cas de maladie génétique à caractère familial. Financé par INCa (Institut national du cancer)  - Coordonné par Sandrine de Montgolfier, Paris; responsable UMR 1027: Emmanuelle Rial-Sebbag; 2013-2015.

Last updated September 10, 2018

French version

Key words

Genomics, Public health, Genetic epidemiology, Immunogenetics, Rheumatoid arthritis, Transplantation, Innovating therapies, Biomarkers, Biobanks, Bioethics, Social sciences, Health law, Interdisciplinarity.

Main publications

Team                                                            27

BERANGER Jérôme (Economiste/gestionnaire santé (Keosys) ; PhD Ethique du numérique santé) @
BERTIER Gabrielle (Doctorante) @
BLASIMME Alessandro (PhD) @
CAMBON-THOMSEN Anne (DR Cnrs) Biography @
CHASSANG Gauthier (ITA) @
CONSTANTIN Anastasia (juriste IE) @
Thibaut (Doctorant) @
DELPLA Pierre-André (MCU-PH) @
DUGUET Anne-Marie (MCU-PH) @
DUGET Julien (Doctorant) @
DUPUI Mathilde @
FAYA ROBLES Alfonsina (Post-doc.) @
GREGOIRE-DELORY Vincent (Doctorant) @
JULIA Sophie (Chercheur) @
LI Mou (Doctorante)
MABILE Laurence (Chargée de projet)
MARCHAND Marie (Doctorante) @

PICHEREAU Delphine (Doctorante) @
RIAL-SEBBAG Emmanuelle (CR1) @ HDR
SEGURA Antonia (TR) @
SERRES Lucie (ITA) @
SOULIER Alexandra (Chercheur) @
TABOULET Florence (PR) @
THOMSEN Mogens (DR2) @
ZHUANG Chuanjuan (Doctorante)
UMR 1027 - Epidémiologie et analyses en santé publique : Risques, maladies chroniques et handicaps - Faculté de médecine 37 allées J. Guesde 31000 Toulouse
Inserm University of Toulouse Université Toulouse III - Paul Sabatier